The cosmetics sector, as well as the nutraceutical sector, is constantly seeking natural ingredients that can combine efficacy and sustainability. One of the most promising innovations in this area is Vitalpep, Sichuan Pepper (Zanthoxylum bungeanum) extract from Rial Pharma, appreciated for its antioxidant and cosmetic properties, among others.

Evaluation antioxidant power of Vitalpep

The ability to combat oxidative stress, assessed by the DPPH (2,2-diphenyl-picrylhydrazyl) method, is one of the most significant qualities of Vitalpep. When the DDPH radical interacts with an antioxidant, it loses its purple coloration, which can be measured spectrophotometrically at 517 nm. Antioxidant activity is expressed as the percentage of DDPH reduction.

The results showed that Vitalpep has 82% antioxidant activity at the concentration of 6 mg/ML, while the IC50 value was estimated to be 3.21 mg/mL. Thus, Vitalpep demonstrated significant antioxidant capacity, with a low IC50, making it potentially useful in nutraceutical and cosmetic applications.

Cosmetic applications and mechanism of action of Vitalpep

The active ingredient in Vitalpep, Hydroxy-a-sanshool, is the bioactive compound responsible for the sensory properties of the extract. It acts primarily on sensory receptors in the skin, specifically on TRP (Transient Receptor Potential) channels, a family of ion channels involved in the transduction of physical and chemical stimuli. The main activated receptors include:

• TRPV1 receptor, known to respond to thermal and chemical stimuli, is also activated by capsaicin and other irritants. Hydroxy-a-sanshool modulates this receptor by reducing sensations of skin discomfort and improving skin tolerability.
• TRPA1 and TRPM8, on the other hand, activated by stinging and cooling stimuli, respectively, contribute to the perception of skin sensations. Stimulation of these receptors by Hydroxy-a-sanshool induces a sensation of relief and freshness, which is useful in formulations for sensitive skin.

Vitalpep cosmetic extract takes advantage of these properties to improve skin comfort by reducing feelings of irritation, inflammation, and itching in specific applications. Vitalpep is particularly suitable for products intended for sensitive or irritated skin due to its ability to reduce itching, inflammation, and irritation. Its soothing effects also make it useful in treatments targeting dermatitis and eczema. In addition, the extract has been shown to be effective in:

• Reducing oxidative stress: thanks to the antioxidant protection offered by sanshools, it counteracts free radical damage and supports skin barrier recovery.
• Providing relief and freshness: ideal for products intended for massage or relaxing treatments, due to the stimulation of TRP receptors, such as TRPV1, TRPA1 and TRPM8.
• Improve skin tolerance: its action on ion channels makes it perfect for hypersensitive skin, increasing hydration and reducing the inflammatory response.

Conclusions

Vitalpep represents an interesting innovation due to its antioxidant properties and unique mechanism of action. From protecting against oxidative stress to reducing skin irritation, Rial Pharma’s Sichuan Pepper extract offers a natural and scientifically validated solution for those who wish to combine wellness and beauty. Adopting ingredients like Vitalpep means investing in skin health while promoting sustainability and innovation. Rial Pharma continues to occupy a prominent position in the supply of advanced raw materials, offering solutions such as Vitalpep that meet the needs of a market increasingly focused on product quality and efficacy.

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