D-Mannose is a simple sugar with a low glycemic index which, once taken, is eliminated through the kidneys, concentrating selectively in the urinary tract. Thanks to its protective action on uroepithelial cells, D-mannose represents a natural and safe alternative for the control of urinary tract infections and infectious cystitis, inhibiting the adhesion of Escherichia coli, the main bacterium responsible for urinary infections, on uroepithelial cells.