Palmitoylethanolamide (PEA) is an endogenous lipid compound (amide of a fatty acid) that has analgesic and anti-inflammatory properties, which inhibits the release of pro-inflammatory mediators by mast cells, immune cells believed to be involved in the onset and maintenance of pain neuropathic. Scientific studies have shown its effectiveness in the treatment of chronic pain syndromes such as sciatica, peripheral neuropathies, diabetic neuropathies, post-herpetic neuralgia but also pelvic pain, osteoarthritis, headaches and post-operative pain.