Papain is a proteolytic enzyme found in papaya juice. Papain has numerous biological properties, including anti-inflammatory and anti-edemic properties, that is, it promotes the reabsorption of edema, ecchymosis and subcutaneous infiltrates. Its main use currently is related to the digestive capacity of the molecule, so it is present in many preparations to improve the digestion of food. Its benefits have also been found in people with HIV and hepatitis B or with insulin-dependent diabetes. Finally, papain reduces the side effects associated with radiation and chemotherapy.